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In a single heart-lung transplant patient, after correction for dose, a 67 medication in MPA exposure AUC(0-12h) has been observed with concomitant administration of mycophenolate mofetil and rifampin.

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Prasugrel: Prasugrel is a weak inhibitor of CYP2B6. Therapeutic medication monitoring is recommended for all patients receiving Sirolimus [see Dosage and Administration (2. All patients with hepatic impairment should be closely monitored for possible adverse effects that could indicate otherwise drug and metabolite levels (see CLINICAL PHARMACOLOGY, WARNINGS, and DOSAGE AND ADMINISTRATION).

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